Cystic Fibrosis Newborn Screening Guidelines
A data-driven national guideline to improve CF newborn screening.
Since 2010, all U.S. states and the District of Columbia have included cystic fibrosis in their newborn screening panels. However, differences in how each state approaches screening algorithms and follow-up procedures can affect how early and accurately infants are diagnosed.
To help address this variation, the Cystic Fibrosis Foundation convened a national committee of experts from multiple fields. The group, which included CPHI's Dr. Marci Sontag, conducted systematic literature reviews and developed seven recommendations aimed at improving the speed and accuracy of CF diagnosis in newborns.
These guidelines offer evidence-informed practices for state screening programs and health professionals involved in CF care. While they provide a structured foundation, individual decisions should always be guided by clinical judgment and the specific needs and values of the infant and family.
The recommendations were published in April 2025 and are available through the International Journal of Neonatal Screening: